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id="c_detail_wrap"> <div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　炎性細(xì)胞因子是由多種細(xì)胞（例如巨噬細(xì)胞、淋巴細(xì)胞、成纖維細(xì)胞等）分泌的一類蛋白質(zhì)，主要在炎癥反應(yīng)和免疫應(yīng)答中發(fā)揮重要作用。它們不僅在正常生理過程中參與細(xì)胞間的溝通，還在病理狀態(tài)下調(diào)節(jié)炎癥反應(yīng)，涉及多種疾病的發(fā)生與發(fā)展，如感染、自身免疫疾病、癌癥等。<br /> </span></span></div><p align="center"><span style="font-size: 14px;"><span style="font-family: 宋體;"><img src="https://img65.chem17.com/gxhpic_3069c9eba7/0497b4e3566c1420dd0f25cff4a1a501f14b41dd248fa5962b8f47f743c41c2e396a09bcaa16cad1_800_800_5.jpg" width="500" height="500" align="middle" alt="" /></span></span></p><p><span style="font-size: 14px;"><span style="font-family: 宋體;"> </span></span></p><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　<strong>炎性細(xì)胞因子</strong>的功能：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　1.調(diào)節(jié)免疫反應(yīng)：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-通過促進(jìn)或抑制不同免疫細(xì)胞的活化，調(diào)節(jié)機(jī)體的免疫反應(yīng)。例如，TNF-α可以增強(qiáng)巨噬細(xì)胞和T細(xì)胞的功能，而IL-10則起到抑制作用。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　2.促進(jìn)炎癥反應(yīng)：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-在感染或組織損傷時(shí)，如IL-1、IL-6及TNF-α可促進(jìn)炎癥細(xì)胞的招募，增強(qiáng)局部的炎癥反應(yīng)，以便快速清除病原體或修復(fù)組織。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　3.驅(qū)動(dòng)細(xì)胞的凋亡和生長(zhǎng)：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-某些細(xì)胞因子有促進(jìn)細(xì)胞凋亡的作用，如TNF-α，而另一些例如EGF和PDGF，則促進(jìn)細(xì)胞增殖和修復(fù)。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　4.參與代謝調(diào)節(jié)：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-還參與全身代謝的調(diào)節(jié)，與胰島素抵抗、肥胖及代謝綜合癥有關(guān)。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　與疾病的關(guān)系：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　1.感染性疾?。?/span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-在細(xì)菌、病毒或其他病原體感染時(shí)，細(xì)胞因子的水平往往顯著升高。例如，細(xì)菌感染會(huì)引起TNF-α和IL-6的急性反應(yīng)，促使白細(xì)胞遷移至感染部位以進(jìn)行清除。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　2.自身免疫性疾?。?/span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-在如風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡等自身免疫性疾病中，失調(diào)是這些疾病活動(dòng)的關(guān)鍵因素。例如，IL-1和IL-6在這些疾病中通常表現(xiàn)為高水平，促進(jìn)持續(xù)的炎癥反應(yīng)。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　3.代謝性疾?。?/span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-近年來的研究表明，慢性低度炎癥與代謝性疾?。ㄈ缣悄虿?、肥胖癥和動(dòng)脈粥樣硬化）密切相關(guān)。如TNF-α、IL-6的升高與胰島素抵抗密切相關(guān)。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　4.腫瘤：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-一些在腫瘤的發(fā)生和發(fā)展中起著雙重作用。它們可以促進(jìn)腫瘤細(xì)胞的增殖和轉(zhuǎn)移，比如IL-6和TNF-α的上調(diào)與腫瘤患者的預(yù)后不良相關(guān)。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　炎性細(xì)胞因子的檢測(cè)：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　1.酶聯(lián)免疫吸附試驗(yàn)（ELISA）：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-該方法利用抗體特異性識(shí)別目標(biāo)細(xì)胞因子，通過顏色變化反映其濃度。ELISA是一種高靈敏度和特異性的檢測(cè)方法。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　2.流式細(xì)胞術(shù)：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-通過標(biāo)記特定的細(xì)胞因子或其受體，使用流式細(xì)胞儀可以同時(shí)檢測(cè)多種細(xì)胞因子的表達(dá)情況。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　3.實(shí)時(shí)定量PCR（qPCR）：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-用于測(cè)定細(xì)胞因子的基因表達(dá)水平，通過分析mRNA的豐度反映其在細(xì)胞中的合成情況。</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　4.免疫組化和免疫熒光：</span></span></div><div><span style="font-size: 14px;"><span style="font-family: 宋體;">　　-通過組織切片中的免疫標(biāo)記，可以定性和定量分析組織中炎癥因子的分布和表達(dá)情況。</span></span></div> </div> <div id="vpqrhi5p5" class="ly_PrevNext"> <i><img src="/skins/535403/images/prev_icon.png" /></i> <ul> <li>上一篇：沒有了</li> <li>下一篇：<a href="/News-1597424.html">多細(xì)胞因子檢測(cè)的五種應(yīng)用詳細(xì)介紹</a></li> </ul> </div> </div> </div> </div>   <div id="vpqrhi5p5" class="foot_box"> <div id="vpqrhi5p5" class="footCon"> <div id="vpqrhi5p5" class="foot_t w1400"> <div id="vpqrhi5p5" class="left"> <div id="vpqrhi5p5" class="foot_nav"> <ul> <li> <dt>關(guān)于我們</dt> <dd><a href="/aboutus.html">公司簡(jiǎn)介</a></dd> <dd><a href="/aboutus.html#ab3">企業(yè)文化</a></dd> 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